| 13316-000 | 146,520 (税別133,200)円 |
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- 病理模型
- 骨格
- 3Dプリント
EZ-317
NEW！大腿骨遠位部の骨肉腫
| 特長 | 本製品の説明は英語のみです。 Product information "Osteosarcoma of femur" Clinical History A 16-year old male presented with a 3-month history of increasingly swollen and painful right knee. On examination, there was a palpable tender swelling above the right knee. Blood test showed a raised Alkaline Phosphatase level. A knee x-ray showed periosteal reactive changes in the distal femur suspicious for a bone malignancy. The patient then underwent staging CT and MRI evaluation of the right leg. He underwent adjuvant chemotherapy prior to resection of his right femur. He made a full recovery. Pathology The specimen is the patient’s excised distal femur. On the cut surface, there is a large pale infiltrating tumour, 10 cm in greatest diameter, extending through the periosteum near the articular surface. This is an osteosarcoma of the femur. Further Information Osteosarcomas are a malignant tumour of bones that are characterised by the production of osteoid matrix or immature bone. It is the most common primary malignancy of bone. Most occur in the distal femur with the tibia and humerus being the most frequent sites affected. Men are more commonly affected than women. They occur in a bimodal age distribution, with most occurring in children and adolescents under 20 years of age and the second peak occurring in older adults over 60. Secondary osteosarcomas are more common in older patients. Secondary osteosarcomas occur in patient’s bones with predisposing conditions such as Paget‘s disease, bone infarcts and previous irradiation. Mutations in tumour suppressors and oncogenes, such as RB, TP53 and INK4a have been shown in osteosarcomas. Osteosarcomas usually present with painful, enlarging masses. Pathological fractures can also be the first presenting complaint. Constitutional symptoms are usually not present. Alkaline phosphatase and lactate dehydrogenase may be elevated on blood tests. X-rays can show features of bone destruction, a mass or signs of a periosteal reaction, such as a sunburst appearance or triangular shells of reactive bone (Codman‘s Triangle). MRI of the affected bone is used to evaluate local staging of the tumour while CT of the body is used to evaluate for distant spread. The tumour may be biopsied in some cases. The lungs are the most common site for distant metastases followed by the bones and brain. Treatment involves neoadjuvant chemotherapy followed by surgery. 5-year survival rate for localised osteosarcoma is 60-70% but this drops to <20% in patients with distant metastases. |
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| 仕様 | エルラージマー社製 |
| 消耗品購入 | |
| 備考 | メーカー品番：MP2115 Erler-Zimmer GmbH & Co.KG の模型製品は、日本国内において株式会社京都科学の独占販売製品です。 |
| 医療機器クラス分類 | なし |
| 特定保守管理医療機器 | 該当なし |
| JANコード | なし |
| 更新年月日 | 2020年06月14日 |